ДИРИКО Кеннет Джон (US),ЭУСТАКУЙО Алессандра С. (US),ГРИН Майкл Эрик (US),ХЭ Хайин (US),ХЕ Мин (US),КОЭН Франк Эрик (US),ОДОННЕЛЛ Кристофер Джон (US),ПУТЕНВЕЕТИЛ Саджит (US),РАТНАЯКЕ Анокха Саяни (US)
申请号：
RU2015115954
公开号：
RU2015115954A
申请日:
2013.10.22
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A compound of formula (I): wherein: the dotted line represents an optional bond Xnezavisimo each selected from the group consisting of: -O-, -S- and -NR- each Xnezavisimo selected from the group consisting of: -O-, -S- and -NR- R c is selected from the group consisting of: -R, -OR, -OCOR, -OCONRR, -OCON (R) NR (R), = O (double bond to oxygen) and -NRR r and are independently selected from the group consisting of: hydrogen and Ci ^ alkyl r and are independently selected from the group consisting of: hydrogen, -OR, oxo -NRRi r and are independently selected from the group consisting of: hydrogen, halogen, hydroxyl and Ci ^ alkyl optionally substituted with 1 -3 substituents, independent mo selected from hydroxyl and halogen, R together with the carbon atom to which they are attached form Salkiliden optionally substituted with 1-3 substituents independently selected from R, r and together represent oxo, iliRi together with the carbon atom to which they are attached, form a 3-5-membered heterocycloalkyl group comprising 1 or 2 heteroatoms independently selected from the group consisting of oxygen, nitrogen and sulfur, wherein said heterocycloalkyl moiety may be optionally substituted with 1-3 substituents independently selected from R Rp edstavlyaet hydrogen, Ci ^ alkyl or -OR are independently selected from hydrogen, groups -Salkil, - (C (R)) - C (O) OR, - (C (R)) - C (O) NRR, - (C ( R)) - NRR, - (C (R)) - N (R) COR, - (C (R)) - C (O) -SR, - (C (R)) - C (O) NRN (R ) R, - (C (R)) - NR-C (O) -NRRi - (C (R)) - NRN (R) R R c is selected from the group consisting of hydrogen, Ci ^ alkyl Skarbotsiklila, Sgeterotsiklila, alkyl-Sarila , alkyl-Sgeteroarila where Rvozmozhno substituted group -NRR or -SONRR r and each independently selected from the group consisting of: hydrogen, hydroxy, -NRR, -NRNR, -Skarbotsiklil groups, -Salkilen-Skarbotsiklil, -Sgeterotsiklil, -Calkilen- Sgeterotsiklil, - (CHCHO) CHCHC (O) OR, - (CHCHO) CHCHNRR, -Calkil, Saril, -Calkilen-Saril and -Sgeter
