ЛАУ Кевин Хоньлюнь (US),ЛИ Венди (US),ЛИССИКАТОС Джозеф П. (US),ПЭЙ Чжонхуа (US),РОБАРДЖ Керк Д. (US)
申请号：
RU2012123956/04
公开号：
RU2012123956A
申请日:
2010.11.10
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A compound of formula I wherein R c is selected from the group consisting of 6-10-membered aryl, 5-9 membered heteroaryl, 3-12 membered heterocycloalkyl, 3-12-membered cycloalkyl, wherein Rzameschen 0-5 substituents R, selected from the group consisting of halogen, F, Cl, Br, I, -NRR, -SR, -OR, -C (O) OR, -C (O) NRR, -C (O) R, -NRC (O) R, - OC (O) R, -NRC (O) NRR, -OC (O) NRR, -NRS (O) NRR, -S (O) R, -S (O) NRR, -R, -NO, -N, = O, -CN, R, -X-NRR, -X-SR, -X-OR, -XC (O) OR, -XC (O) NRR, -XC (O) R, -X-NRC (O ) R, -X-OC (O) R, -X-NRC (O) NRR, -X-OC (O) NRR, -X-NRS (O) NRR, -XS (O) R, -XS (O ) NRR, -X-NO, -XN, -X-CN, and XR wherein R each independently selected from hydrogen. Alkyl, Sgalogenalkila, Sgeteroalkila, alkenyl, alkynyl, cycloalkyl, Cgeterotsikloalkila, phenyl and - (CH) -phenyl, optionally r and R, when attached to the same nitrogen atom are combined to form a 3-6 membered heterocyclic ring containing 1 or 2 heteroatoms selected from N, O and S R c is selected from Ci ^ alkyl Cgalogenalkila, alkenyl, Calkinila, Ctsikloalkila, Cgeterotsikloalkila, phenyl and - (CH) -phenyl Hvybran from the group consisting of Calkilena, and Calkenilena Calkinilena and R c is selected from the group consisting of phenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-imidazolyl, 2-indolyl, 1-naphthyl, 2-naphthyl, 2-thienyl, 3-thienyl, 2-pyrrolyl, 2 -furans and 3-furanyl, and wherein Rzameschen 0-3 substituents selected from F, Cl, Br, I, -NRR, -SR, -OR, -S (O) R, -S (O) NRR, -NO , -N, = O, -CN, pyridyl, Ci ^ alkyl, alkenyl, and Calkinila Cgeteroalkila R c is selected from the group consisting of hydrogen, Ci ^ alkyl, alkenyl, Calkinil, Cgeteroalkil, 6-10 membered aryl, 5-10 membered heteroaryl, 3 -12-membered heterocycloalkyl, 3-12-membered cycloalkyl, -L-Caril, -L-Cgeteroaril, -L-Ctsikloalkil and -L-Cgeterotsikloalkil where L shaven n of Calkilena, Calkenilena, and Calkinilena Cgeteroalkilena and wherein Rzameschen 0-5 substituents R, selected from the group consisting of halogen, F, Cl,
