НАКАМУРА Юсуке (JP),МАЦУО Е (JP),ХИСАДА Содзи (JP),АХМЕД Ферьян (US),ХАНТЛИ Рэймонд (US),САДЖДЖАДИ-ХАШЕМИ Зохрех (US),ДЖЕНКИНС Дэвид М. (US),КАРГБО Роберт Б. (US),ЦУЙ Вэнэ (US),ГОУАН Поливина Холисия
申请号：
RU2012145855/04
公开号：
RU2012145855A
申请日:
2011.03.29
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A compound represented by the general formula I or a pharmaceutically acceptable salt thereof, wherein each R, R, r and independently represents a group selected from the group consisting of: hydrogen, hydroxyl, halogen, cyano, nitro, amino, C-Ci ^ alkyl, C -Calkenila, C-Calkinila, C-Ctsikloalkila, C-Ctsikloalkenila, C-alkoxy, C-Carila, indanyl, heteroaryl, 3-8-membered heterocycloalkyl, -OSOCH, -OSOCF, -CONH, -OCONRR, wherein each r and independently represents hydrogen, C-Ci ^ alkyl or R R, taken together form a morpholinyl, -OCOR, wherein R is C-Ci ^ alkyl and-OCOOR, wherein Rp Representing a C-Ci ^ alkyl, wherein R, R, r and Rneobyazatelno substituted with a substituent independently selected from the group consisting of substituent A wherein the A substituent is independently selected from the group consisting izgidroksila oxo (= O) cyano halo C- alkyl optionally substituted with a substituent B C-Ctsikloalkila optionally substituted with cyano or C-Calkilom substituted -NRR, wherein r and each independently represents hydrogen or C-Ci ^ alkyl -NRR, wherein r and each independently represents hydrogen C-alkyl optionally substituted by hydroxy, amino, di (C-Ci ^ alkyl) amino, -SO (C-Calkilom), 3-8 membered heterocycloalkyl or cyano or a 3-8 membered heterocycloalkyl optionally substituted with -COOR, wherein R is C-Ci ^ alkyl C-alkoxy optionally substituted by halogen, 3-8-membered heterocycloalkyl, optionally substituted C-Calkilom or -NRR, where each r and independently represents hydrogen, C-alkylsulfonyl, or C-alkyl optionally substituted with C-Calkilsulfonilom or di (C-Ci ^ alkyl) amino -SONRR, wherein r and each independently represents hydrogen C-alkyl optionally for
