ЛИ Венди (US),ЛИССИКАТОС Джозеф П. (US),ПЭЙ Чжунхуа (US),РОБАРДЖ Кирк Д. (US)
申请号：
RU2012122366/04
公开号：
RU2012122366A
申请日:
2010.11.10
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A compound of formula I: wherein Y and Ykazhdy independently represents N or C (R), but Y and Yoba not represent N or both do not represent C (R), wherein R c is selected from the group consisting of hydrogen, Ci ^ alkyl, alkenyl, Calkinila, Cgeteroalkila, 6-10-membered aryl, 5-9 membered heteroaryl, 3-12 membered heterocycloalkyl, 3-12-membered cycloalkyl, wherein substituents R b Rzameschen amount of from 0 to 5, selected from the group consisting of a halogen atom , F, Cl, Br, I, -NRR, -SR, -OR, -C (O) OR, -C (O) NRR, -C (O) R, -NRC (O) R, -OC (O ) R, -NRC (O) NRR, -OC (O) NRR, -NRS (O) NRR, -S (O) R, -S (O) NRR, -R, -NO, -N, = O, -CN, R, -X-NRR, -X-SR, -X-OR, -XC (O) OR, -XC (O) NRR, -XC (O) R, -X-NRC (O) R, -X-OC (O) R, -X-NRC (O) NRR, -X-OC (O) NRR, -X-NRS (O) NRR, -XS (O) R, -XS (O) NRR, -X-NO, -XN, -X-CN, and XR wherein R each independently selected from hydrogen, Ci ^ alkyl Sgalogenoalkila, Cgeteroalkila, alkenyl, Calkinila, Ctsikloalkila, Cgeterotsikloalkila, phenyl and - (CH) -phenyl, optionally r and R, when attached to the same nitrogen atom are combined to form 3-6 membered heterocyclic ring containing from 1 to 2 heteroatoms selected from N, O and S R c is selected from Ci ^ alkyl Cgalogenoalkila, alkenyl, Calkinila, Ctsikloalkila, Cgeterotsikloalkila, phenyl and - (CH) -phenyl Xvybran from the group consisting of Calkilena, and Calkenilena Calkinilena and R c is selected from the group consisting of phenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-imidazolyl, 2-indolyl, 1-naphthyl, 2-naphthyl, 2-thienyl, 3-thienyl, 2-pyrrolyl, 2 -furans and 3-furanyl, and wherein Rzameschen substituents in an amount of from 0 to 3, selected from F, Cl, Br, I, -NRR, -SR, -OR, -S (O) R, -S (O) NRR , -NO, -N, = O, -CN, pyridyl, Ci ^ alkyl, alkenyl, and Calkinila Cgeteroalkila R c is selected from the group consisting of hydrogen, Ci ^ alkyl, alkenyl, Calkinila, Cgeteroalkila, -L-Carila, -L-Cgeteroarila, -L-Ctsikloalkila and -L-Cgeterotsikloalkila where L shaven
