МАКРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ КИНАЗЫ LRRK2

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专利权人:

ИПСЕН ФАРМА С.А.С. (FR)

发明人:

ХОФЛАК Ян (BE),БЛОМ Петра (BE)

申请号：

RU2014117515/04

公开号：

RU2014117515A

申请日:

2012.09.28

申请国别(地区):

RU

年份:

2015

代理人:

摘要：

1. A compound of Formula I or a stereoisomer, tautomer, racemic, metabolite, prodrug or prodrug, salt, hydrate, N-oxide form thereof or a solvate thereof: wherein Au Avybirayut of C and N wherein when Apredstavlyaet is C, then a Apredstavlyaet Ν and wherein when Apredstavlyaet is C, then a Apredstavlyaet Ν Rvybirayut of -H, -halogen, -OH, -Clkila, -Stsikloalkila, -O-C ^ alkyl, -S-Ci ^ alkyl, -NRR, - (C = O) -R , SO-R, -CN, -NR-SO-R, -Het wherein each of said alkylene is optionally and independently substituted with 1-3 substituents selected from -halo, -OH, -NRR, -O-Ci ^ alkyl, -S-Ci ^ alkyl Rvybirayut of -H, -halogen, -OH, -Salkila, -Stsikloalkila, -O-C ^ alkyl, -S-Ci ^ alkyl, - (C = O) -Calkila, (C = O) -O-Ci ^ alkyl, - (C = O) -NRR, -Het, - (C = O) -Het, -SO-Ci ^ alkyl wherein each of said Calkilov is optionally and independently substituted with 1-3 substituents selected from -halo, -OH, -O-C ^ alkyl, -S-Ci ^ alkyl, -Het, -Ar, -NRR Rvybirayut of -Η, -halo, -OH -Calkila, -Stsikloalkila, -O-C ^ alkyl, -S-Ci ^ alkyl, - (C = O) -Salkila, (C = O) -O-C ^ alkyl, -Het, - (C = O) -Het, - (C = O) -NRR, -SO-Ci ^ alkyl wherein each of said alkylene is optionally and independently substituted with 1-3 substituents selected from -halo, -OH, -OCalkila, -SCalkila, -NRR, -Het, -Ar Rvybirayut of -halo, -OH, -Salkila - O-C ^ alkyl, -S-Ci ^ alkyl, -NRR, -Het r and R, are each independently selected from -H, -halo, -Calkila, -OCalkila, -S-Ci ^ alkyl, -Het, -Ar, -Stsikloalkila - SO-Ar, -SO, -SO-alkyl, - (C = O) - (C = O) -Salkila, -O- (C = O) -Calkila, - (C = O) -O-alkyl wherein each of said alkylene is optionally and independently substituted with 1-3 substituents selected from -halo, -OH, -OCalkila, -SCalkila, -Het, -NRR Rvybirayut from -SO, -SO-alkyl, - (C = O ), - (C = S), - (C = O) -O-C ^ alkyl, - (C = S) -O-alkyl, - (C = O) -Salkila, - (C = O) -Calkenila - (C = S) -Salkila, - (C = S) -Salkenila, -Salkil- (C = O) -NRR, -Salkil- (C = S) -NRR, -Salkil-R (C = O) -NR

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