1. A method of treating a subject suffering from a disease or condition mediated Flt3, or at risk of developing such disease or condition, comprising administering to said subject an effective amount of a compound having the chemical structure of Formula IIIlyubyh its salts, prodrugs, tautomers and isomers wherein: a Lpredstavlyaet -CH-, -CHCH-, -CH (R) -, -C (O) - or -C (O) NH- R c is selected from the group consisting of hydrogen, -OR, -CN, fluorine, chlorine, lower alkyl substituted fluoro lower alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl When this cycloalkyl, heterocycloalkyl, aryl or heteroaryl optionally substituted with one or more substituents selected from the group consisting of halogen, lower alkyl, fluoro substituted lower alkyl, -NHR, -NRR, -ORi -S (O) R R c is selected from the group consisting of hydrogen, Ci ^ alkyl, substituted by fluorine alkyl, OH, alkoxy, and substituted fluorine-alkoxy R is heterocycloalkyl, heteroaryl, or a kotoromukazyvaet at the point of attachment Rk Liz Formula III, wherein heterocycloalkyl or heteroaryl are optionally substituted with one or more substituents selected from the group consisting of halogen, lower alkyl, fluoro substituted lower alkyl, cycloalkylamino, -NHR, -NRR, -ORi -S (O) R R, R, R, r and are independently selected from the group consisting of hydrogen, halogen, lower alkyl, fluoro substituted lower alkyl, cycloalkylamine about, -NHS (O) R, -NHC (O) R, -NHR, -NRR, -ORi -S (O) R R c is selected from the group consisting of lower alkyl and lower alkyl substituted by fluorine are independently selected at each occurrence from the group consisting of lower alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, wherein lower alkyl is optionally
