Isoxazole derivatives as mutant isocitrate dehydrogenase 1 inhibitors

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专利权人:

第一三共株式会社;国立研究開発法人国立がん研究センター

发明人:

齋藤 昭一,伊藤 雅夫,藤沢 哲則,斉藤 博直,清塚 洋平,渡邉 秀昭,松永 大典,神子島 佳子,鈴木 徹也,小川原 陽子,北林 一生

申请号：

JP2016552161

公开号：

JP6087033B2

申请日:

2015.10.01

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

It has been found that a compound of the general formula (I) having an isoxazole skeleton has excellent inhibitory activity against mutant IDH1 protein and inhibits the production of 2-HG by this protein, while the compound is also capable of effectively inhibiting the growth of various tumors expressing the protein. In the formula, R 1 , R 2 , R 3 , Y, and Z are as defined in claim 1.

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