DERIVAT IZOKSAZOLA KAO INHIBITOR MUTANTNE IZOCITRATNE DEHIDROGENAZE 1

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专利权人:

DAIICHI SANKYO COMPANY, LIMITED;NATIONAL CANCER CENTER

发明人:

FUJISAWA, TETSUNORI,OGAWARA, YOKO,WATANABE, HIDEAKI,KAGOSHIMA, YOSHIKO,SAITO, SHOICHI,SAITO, HIRONAO,KIYOTSUKA, YOHEI,MATSUNAGA, HIRONORI,SUZUKI, TETSUYA,KITABAYASHI, KAZUO,ITOH, MASAO

申请号：

RSP20200290

公开号：

RS60064B1

申请日:

2015.10.01

申请国别(地区):

RS

年份:

2020

代理人:

摘要：

It has been found that a compound of the general formula (I) having an isoxazole skeleton has excellent inhibitory activity against mutant IDH1 protein and inhibits the production of 2-HG by this protein, while the compound is also capable of effectively inhibiting the growth of various tumors expressing the protein. In the formula, R 1 , R 2 , R 3 , Y, and Z are as defined in claim 1.

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中国工程科技知识中心

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http://www.ckcest.cn/home/