NATIONAL CANCER CENTER;DAIICHI SANKYO COMPANY LIMITED
发明人:
申请号：
IL25130517
公开号：
IL251305D0
申请日:
2017.03.21
申请国别(地区):
IL
年份:
2017
代理人:
摘要：
It has been found that a compound of the general formula (I) having an isoxazole skeleton has excellent inhibitory activity against mutant IDH1 protein and inhibits the production of 2-HG by this protein, while the compound is also capable of effectively inhibiting the growth of various tumors expressing the protein. In the formula, R 1 , R 2 , R 3 , Y, and Z are as defined in claim 1.
