POCHODNA IZOKSAZOLU JAKO INHIBITOR ZMUTOWANEJ DEHYDROGENAZY IZOCYTRYNIANOWEJ 1

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专利权人:

Daiichi Sankyo Company, Limited;National Cancer Center

发明人:

SAITO, SHOICHI,ITOH, MASAO,FUJISAWA, TETSUNORI,SAITO, HIRONAO,KIYOTSUKA, YOHEI,WATANABE, HIDEAKI,MATSUNAGA, HIRONORI,KAGOSHIMA, YOSHIKO,SUZUKI, TETSUYA,OGAWARA, YOKO,KITABAYASHI, KAZUO

申请号：

PL15845549

公开号：

PL3202766T3

申请日:

2015.10.01

申请国别(地区):

PL

年份:

2020

代理人:

摘要：

It has been found that a compound of the general formula (I) having an isoxazole skeleton has excellent inhibitory activity against mutant IDH1 protein and inhibits the production of 2-HG by this protein, while the compound is also capable of effectively inhibiting the growth of various tumors expressing the protein. In the formula, R 1 , R 2 , R 3 , Y, and Z are as defined in claim 1.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/