DERIVAT IZOKSAZOLA KAO INHIBITOR MUTIRANE IZOCITRATNE DEHIDROGENAZE 1

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专利权人:

National Cancer Center;Daiichi Sankyo Company, Limited

发明人:

Saito, Shoichi,Itoh, Masao,Fujisawa, Tetsunori,Saito, Hironao,Kiyotsuka, Yohei,Watanabe, Hideaki,Matsunaga, Hironori,Kagoshima, Yoshiko,Suzuki, Tetsuya,Ogawara, Yoko,Kitabayashi, Kazuo

申请号：

HRP20200395

公开号：

HRP20200395T1

申请日:

2020.03.10

申请国别(地区):

HR

年份:

2020

代理人:

摘要：

It has been found that a compound of the general formula (I) having an isoxazole skeleton has excellent inhibitory activity against mutant IDH1 protein and inhibits the production of 2-HG by this protein, while the compound is also capable of effectively inhibiting the growth of various tumors expressing the protein. In the formula, R 1 , R 2 , R 3 , Y, and Z are as defined in claim 1.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/