ISOXAZOLE DERIVATIVE AS MUTERATED ISOCITRATE DEHYDROGENASE 1 INHIBITOR

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专利权人:

DAIICHI SANKYO COMPANY, LIMITED;National Cancer Center

发明人:

SAITO, Shoichi,ITOH, Masao,FUJISAWA, Tetsunori,SAITO, Hironao,KIYOTSUKA, Yohei,WATANABE, Hideaki,MATSUNAGA, Hironori,KAGOSHIMA, Yoshiko,SUZUKI, Tetsuya,OGAWARA, Yoko,KITABAYASHI, Kazuo

申请号：

DK15845549

公开号：

DK3202766T3

申请日:

2015.10.01

申请国别(地区):

DK

年份:

2020

代理人:

摘要：

It has been found that a compound of the general formula (I) having an isoxazole skeleton has excellent inhibitory activity against mutant IDH1 protein and inhibits the production of 2-HG by this protein, while the compound is also capable of effectively inhibiting the growth of various tumors expressing the protein. In the formula, R 1 , R 2 , R 3 , Y, and Z are as defined in claim 1.

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中国工程科技知识中心

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http://www.ckcest.cn/home/