JAROSKOVA, LIBUSE,LINDERS, JOANNES, THEODORUS, MARIA,VAN DER VEKEN, LOUIS, JOZEF, ELISABETH,WILLEMSENS, GUSTAAF, HENRI, MARIA,BISCHOFF, FRANCOIS PAUL
申请号：
HK09102100.4
公开号：
HK1124528B
申请日:
2009.03.04
申请国别(地区):
HK
年份:
2014
代理人:
摘要：
the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Z represents O, S, NR6, SO or SO2； R1 represents hydrogen, cyano, hydroxy, or C1-4alkyl optionally substituted with halo, R2 represents hydrogen, C1-4alkyl, or C1-4alkyloxy-； R3 represents hydrogen, C1-4alkyl, C1-4alkyloxy- or R3 combined with R2 form together a divalent radical selected from the group consisting of &mdash；O&mdash；CH2&mdash； (a), &mdash；NR7&mdash；CH2&mdash； (b), &mdash；(CR8R9)m- (c) and &mdash；CR10&boxH； (d) wherein m represents 1 or 2 and R7, R8, R9 and R10 are each independently selected from hydrogen or C1-4alkyl； R4 represents hydrogen, halo, hydroxy, cyano, amino, NR11R12, C1-4alkyloxy- optionally substituted with one or where possible two or three substituents selected from hydroxy and halo or R4 represents C1-4alkyl optionally substituted with one or where possible two or three substituents selected from hydroxy and halo； R5 represents hydrogen, halo, cyano, amino, phenyl, hydroxy, C1-4alkyloxycarbonyl, hydroxycarbonyl, NR13R14 or C1-4alkyl substituted with one or more substituents selected from hydroxycarbonyl, phenyl, C1-4alkyloxy or NR15R16； R6 represents hydrogen； R11 and R12 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-； R13 and R14 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-； R15 and R16 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-； R17 and R18 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-.
