Libuse Jaroskova;François Paul Bischoff;Louis Jozef Elisabeth Van Der Veken;Gustaaf Henri Maria Willemsens;Joannes Theodorus Maria Linders
发明人:
Libuse Jaroskova,Joannes Theodorus Maria Linders,Louis Jozef Elisabeth Van Der Veken,Gustaaf Henri Maria Willemsens,François Paul Bischoff
申请号：
US11661470
公开号：
US08344181B2
申请日:
2005.08.26
申请国别(地区):
US
年份:
2013
代理人:
摘要：
the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, whereinZ represents O, S, NR6, SO or SO2；R1 represents hydrogen, cyano, hydroxy, or C1-4alkyl optionally substituted with halo,R2 represents hydrogen, C1-4alkyl, or C1-4alkyloxy-；R3 represents hydrogen, C1-4alkyl, C1-4alkyloxy- or R3 combined with R2 form together a divalent radical selected from the group consisting of —O—CH2— (a), —NR7—CH2— (b), —(CR8R9)m- (c) and —CR10═ (d) wherein m represents 1 or 2 and R7, R8, R9 and R10 are each independently selected from hydrogen or C1-4alkyl；R4 represents hydrogen, halo, hydroxy, cyano, amino, NR11R12, C1-4alkyloxy- optionally substituted with one or where possible two or three substituents selected from hydroxy and halo or R4 represents C1-4alkyl optionally substituted with one or where possible two or three substituents selected from hydroxy and halo；R5 represents hydrogen, halo, cyano, amino, phenyl, hydroxy, C1-4alkyloxycarbonyl, hydroxycarbonyl, NR13R14 or C1-4alkyl substituted with one or more substituents selected from hydroxycarbonyl, phenyl, C1-4alkyloxy or NR15R16；R6 represents hydrogen；R11 and R12 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-；R13 and R14 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-；R15 and R16 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-；R17 and R18 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-.
