Laurence Anne Mevellec;Eddy Jean Edgard Freyne;Pierre-Henri Storck;Peter Ten Holte;Marc Willems;Alexandra Papanikos;Werner Constant Johan Embrechts
发明人:
Alexandra Papanikos,Eddy Jean Edgard Freyne,Peter Ten Holte,Marc Willems,Werner Constant Johan Embrechts,Laurence Anne Mevellec,Pierre-Henri Storck
申请号：
US12373404
公开号：
US08492377B2
申请日:
2007.07.12
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention concerns the compounds of formulathe N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, whereinY represents —C3-9alkyl-, —C1-5alkyl-NR6—C1-5alkyl- or —C1-5alkyl-NR7—CO—C1-5alkyl-；X1 represents —O —；X2 represents NR5—C1-2alkyl-；R1 represents hydrogen, halo or Het3-O—；R2 represents hydrogen；R3 represents hydroxy, C1-4alkyloxy- or C1-4alkyloxy substituted with one or two substituents each independently selected from Het4, hydroxy, C1-4alkyloxy-, C1-4alkyloxy-C1-4alkyloxy and NR9R10；R5 represents hydrogen or C1-4alkyl；R6 represents hydrogen or C1-4alkyl；R7 represents hydrogen；R9 and R10 each independently represent hydrogen； C1-4alkyl-S(═O)2—C1-4alkyl-C(═O)—； C1-4alkyl or C1-4alkyl substituted with hydroxy；Het3 represents pyridinyl optionally substituted with C1-4alkyl；Het4 represents morpholinyl, piperidinyl or piperazinyl wherein said Het4 is optionally substituted with hydroxy-C1-4alkyl or C1-4alkyl-S(═O)2—C1-4alkyl-.
