Eddy Jean Edgard Freyne,Peter Jacobus Johannes Buijnsters,Kristof Van Emelen,Werner Constant Johan Embrechts,Timothy Pietro Suren Perera
申请号：
US13796377
公开号：
US09040511B2
申请日:
2013.03.12
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention concerns the compounds of formulathe N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, whereinZ represents NHY represents —C3-9alkyl-, —C1-5alkyl-NR12—C1-5alkyl-, —C1-6alkyl-NH—CO— or —CO—NH—C1-6alkyl-X1 represents —O—X2 represents a direct bond, —NR11—C1-2alkyl-, —NR11—CH2—, —C1-2alkyl-, —O—C1-2alkyl, —O— or —O—CH2—R1 represents hydrogen or haloR2 represents hydrogen, cyano, halo, hydroxycarbonyl-, C1-4alkyloxycarbonyl-, Het16-carbonyl- or Ar5R3 represents hydrogen, hydroxy, C1-4alkyloxy-, Ar4—C1-4alkyloxy or R3 represents C1-4alkyloxy substituted with one or where possible two or more substituents selected from C1-4alkyloxy- or Het2-R10 represents hydrogenR11 represents hydrogen, C1-4alkyl- or C1-4alkyl-oxy-carbonyl-R12 represents Het14-C1-4alkyl, in particular morpholinyl-C1-4alkylHet2 represents a heterocycle selected from morpholinyl or piperidinyl optionally substituted with C1-4alkyl-, preferably methylHet14 represents morpholinylHet16 represents a heterocycle selected from morpholinyl or pyrrolidinylAr4 represents phenylAr5 represents phenyl optionally substituted with cyano.
