EDDY JEAN EDGARD FREYNE,MARC WILLEMS,PIERRE HENRI STORCK,VIRGINIE SOPHIE PONCELET,KRISTOF VAN EMELEN,PETER JACOBUS JOHANNES ANTONIUS BUIJNSTERS,WERNER CONSTANT JOHAN EMBRECHTS,TIMOTHY PIETRO SUREN PER
申请号：
MYPI 20045196
公开号：
MY146415A
申请日:
2004.12.16
申请国别(地区):
MY
年份:
2012
代理人:
摘要：
THE PRESENT INVENTION CONCERNS THE COMPOUNDS OF FORMULA THE N-OXIDE FORMS, THE PHARMACEUTICALLY ACCEPTABLE ADDITION SALTS AND THE STEREOCHEMICALLY ISOMERIC FORMS THEREOF, WHEREIN AL-A2=A3-A4 REPRESENTS A DIVALENT RADICAL SELECTED FROM N-CH=CH-CH, N-CH=N-CH OR CH-CH=N-CH Z REPRESENTS NH Y REPRESENTS -C3-9ALKYL-, -C1-5ALKYL-NR13-C1-5ALKYL-,-C1-6ALKYL-NH-CO- OR CO-NH –C1-6ALKYL- X1 REPRESENTS -O- OR -NR II_ X2 REPRESENTS -CI-2ALKYL-, -O-CI-2ALKYL, -O- OR -O-CH2- R1 REPRESENTS HYDROGEN OR HALO R2 REPRESENTS HYDROGEN, CYANO, HALO, HYDROXYCARBONYL-, C1-4ALKYLOXYCARBONYL-, HETI6-CARBONYL- OR AR5 R3 REPRESENTS HYDROGEN R4 REPRESENTS HYDROXY, C1-4ALKYLOXY-, AR4 –C1-4ALKYLOXY OR R4 REPRESENTS C1-4ALKYLOXY SUBSTITUTED WITH ONE OR WHERE POSSIBLE TWO OR MORE SUBSTITUENT SELECTED FROM C1-4ALKYLOXY- OR HET2- R11 REPRESENTS HYDROGEN R12 REPRESENTS HYDROGEN, C1-4ALKYL- OR C1-4ALKYL-OXY-CARBONYL- R13 REPRESENTS HET14-C1-4ALKYL, IN PARTICULAR MORPHOLINYL-C1-4ALKYL HET2 REPRESENTS A HETEROCYCLE SELECTED FROM MORPHOLINYL OR PIPERIDINYL OPTIONALLY SUBSTITUTED WITH C1-4ALKYL-, PREFERABLY METHYL HETL4 REPRESENTS MORPHOLINYL HETL6 REPRESENTS A HETEROCYCLE SELECTED FROM MORPHOLINYL OR PYRROLIDINYL AR4 REPRESENTS PHENYL AR5 REPRESENTS PHENYL OPTIONALLY SUBSTITUTED WITH CYANO.
