Eddy Jean Edgard Freyne,Marc Willems,Pierre Henri Storck,Virginie Sophie Poncelet,Kristof Van Emelen,Peter Jacobus Johnnes Antonius Buijnsters,Werner Constant Johan Embrechts,Timothy Pietro Suren Pere
申请号：
US12724203
公开号：
US08772272B2
申请日:
2010.03.15
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention concerns the compounds of formulathe N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, whereina1-a2=a3-a4 represents a divalent radical selected from N—CH═CH—CH, N—CH═N—CH or CH—CH═N—CHZ represents NH Y represents —C3-9alkyl-, —C1-5alkyl-NR13—C1-5alkyl-, —C1-6alkyl-NH—CO— or —CO—NH—C1-6alkyl-X1 represents —O— or —NR11— X2 represents —C1-2alkyl-, —O—C1-2alkyl, —O— or —O—CH2—R1 represents hydrogen or haloR2 represents hydrogen, cyano, halo, hydroxycarbonyl-, C1-4alkyloxycarbonyl-, Het16-carbonyl- or Ar5 R3 represents hydrogenR4 represents hydroxy, C1-4alkyloxy-, Ar4—C1-4alkyloxy or R4 represents C1-4alkyloxy substituted with one or where possible two or more substituents selected from C1-4alkyloxy- or Het2-R11 represents hydrogenR12 represents hydrogen, C1-4alkyl- or C1-4alkyl-oxy-carbonyl-R13 represents Het14-C1-4alkyl, in particular morpholinyl-C1-4alkylHet2 represents a heterocycle selected from morpholinyl or piperidinyl optionally substituted with C1-4alkyl-, preferably methylHet14 represents morpholinylHet16 represents a heterocycle selected from morpholinyl or pyrrolidinylAr4 represents phenyl Ar5 represents phenyl optionally substituted with cyano.
