Freyne, Eddy Jean Edgard,Embrechts, Werner Constant Johan,Willems, Marc,Holte, Peter Ten,Papanikos, Alexandra,Storck, Pierre Henri,Poncelet, Virginie Sophie
申请号：
NO20073426
公开号：
NO339891B1
申请日:
2007.07.05
申请国别(地区):
NO
年份:
2017
代理人:
摘要：
The present invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Z represents NH Y represents &mdashC3-9alkyl-, &mdashC1-5alkyl-NR13&mdashC1-5alkyl-, &mdashC1-5alkyl-NR14&mdashCO&mdashC1-5alkyl-, &mdashC1-2alkyl-NR21&mdashH2&mdashCO&mdashNH&mdashC1-3alkyl- or &mdashC1-2alkyl-NR23&mdashCO&mdashCR16R17&mdashNH&mdash X1 represents O or &mdashO&mdashC1-2alkyl- X2 represents a direct bond, C1-2alkyl, &mdashCO&mdashC1-2alkyl or NR12&mdashC1-2alkyl R1 represents hydrogen or halo R2 represents halo, acetylene or Het1 R3 represents hydrogen or cyano R4 represents Ar4&mdashC1-4alkyloxy-, C1-4alkyloxy- or C1-4alkyloxy substituted with one or where possible two or more substituents selected from Het2, NR7R8, hydroxy and C1-4alkyloxy-C1-4alkyloxy- R7 represents hydrogen or C1-4alkyl R8 represents C1-4alkyl substituted with NR25R26 or C1-4alkylsulfonyl R12 represents hydrogen or C1-4alkyl- R13 represents Ar6-sulfonyl or C1-6alkyloxycarbonyl optionally substituted with phenyl R16 and R17 represents hydrogen, C1-4alkyl or R16 and R17 taken together with the carbon atom to which they are attached from a C3-6cycloalkyl R23 represents C1-4alkyl and R23 represents hydrogen when R16 and R17 taken together with the carbon atom to which they are attached from a C3-6cycloalkyl R25, R26, R27 and R28 each independently represent hydrogen or C1-4alkylcarbonyl Het1 represents 2-bora-1,3-dioxolanyl Het2 represents piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl or 1,1-dioxothiomorpholinyl wherein said Het2 is optionally substituted with C1-4alkyloxycarbonyl or NR27R28&mdashC1-4alkyl Ar4 and Ar5 represents phenyl Ar6 represents phenyl optionally substituted with nitro.
