EDDY JEAN EDGARD FREYNE,MARC WILLEMS,PETER TEN HOLTE,ALEXANDRA PAPANIKOS,WERNER CONSTANT JOHAN EMBRECHTS,PIERRE HENRI STORCK,VIRGINIE SOPHIE PONCELET
申请号：
MYPI 20055704
公开号：
MY148503A
申请日:
2005.12.06
申请国别(地区):
MY
年份:
2013
代理人:
摘要：
THE PRESENT INVENTION CONCERNS THE COMPOUNDS OF FORMULA THE N-OXIDE FORMS, THE PHARMACEUTICALLY ACCEPTABLE ADDITION SALTS AND THE STEREOCHEMICALLY ISOMERIC FORMS THEREOF, WHEREIN Z REPRESENTS NH Y REPRESENTS -C3-9ALKYL-,-C1-5ALKYL-NR13-C1-5ALKYL-, -C1-5ALKYL-NR14-CO-C1-5ALKYL-, -C1-2ALKYL-NR21-H2-C0-NH-C1-3ALKYL- OR –C1-2ALKYL-NR23-CO-CR16R17-NH- X1 REPRESENTS O OR -O-C1-2ALKYL- X2 REPRESENTS A DIRECT BOND, C1-2ALKYL, -CO-C1-2ALKYL OR NR12-C1-2ALKYL R1 REPRESENTS HYDROGEN OR HALO R2 REPRESENTS HALO, ACETYLENE OR HET1 R3 REPRESENTS HYDROGEN OR CYANO R4 REPRESENTS AR4-C1-4ALKYLOXY-, C1-4ALKYLOXY- OR C1-4ALKYLOXY SUBSTITUTED WITH ONE OR WHERE POSSIBLE TWO OR MORE SUBSTITUENTS SELECTED FROM HET2, NR7R8, HYDROXY AND C1-4ALKYLOXY-C1-4ALKYLOXY- R7 REPRESENTS HYDROGEN OR C1-4ALKYL R8 REPRESENTS C1-4ALKYL SUBSTITUTED WITH NR25R26 OR C1-4ALKYLSULFONYL R12 REPRESENTS HYDROGEN OR C1-4ALKYL- R13 REPRESENTS AR6-SULFONYL OR C1-6ALKYLOXYCARBONYL OPTIONALLY SUBSTITUTED WITH PHENYL R16 AND R17 REPRESENTS HYDROGEN, C1-4ALKYL OR R16 AND R17 TAKEN TOGETHER WITH THE CARBON ATOM TO WHICH THEY ARE ATTACHED FROM A C3-6CYCLOALKYL R23 REPRESENTS C1-4ALKYL AND R23 REPRESENTS HYDROGEN WHEN R16 AND R17 TAKEN TOGETHER WITH THE CARBON ATOM TO WHICH THEY ARE ATTACHED FROM A C3-6CYCLOALKYL R25, R26, R27 AND R28 EACH INDEPENDENTLY REPRESENT HYDROGEN OR C1-4ALKYLCARBONYL HET1 REPRESENTS 2-BORA-1, 3-DIOXOLANYL HET2 REPRESENTS PIPERIDINYL, PIPERAZINYL, MORPHOLINYL, THIOMORPHOLINYL OR 1, 1-DIOXOTHIOMORPHOLINYL WHEREIN SAID HET2 IS OPTIONALLY SUBSTITUTED WITH C1-4 ALKYLOXYCARBONYL OR NR27R28-C1-4ALKYL AR4 AND AR5 REPRESENTS PHENYL AR6 REPRESENTS PHENYL OPTIONALLY SUBSTITUTED WITH NITRO.
