CHATTERJEE, Arnab Kumar,NAGLE, Advait Suresh,PARASELLI, Prasuna,KONDREDDI, Ravinder Reddy,LEONG, Seh Yong,MISHRA, Pranab Kumar,MOREAU, Robert Joseph,ROLAND, Jason Thomas,SIM, Wei Lin Sandra,SIMON, Oli
申请号：
ES13795977
公开号：
ES2655030T3
申请日:
2013.11.18
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula I, ** Formula ** or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein n is 0, 1, 2 or 3； p is 0, 1, 2 or 3； L is selected from the group consisting of * - (CHR3) 1-3-, * -CHR3N (R2) -, * -CHR3O-, * -CHR3S-, * -CHR3S (O) -, * - CHR3N (R2) CHR3-, * -C (O) -, * -C (O) N (R2) -, * -C (O) N (R2) CHR3-, * -N (R2) -, * -N (R2) CHR3-, * -N (R2) C (O) -, * - N (R2) C (O) N (R2) -, * -N (R2) S (O) 2-, in which * represents the point of attachment of L to the ring condensed with pyrazolo [1,5-a] pyridine represented in formula I； each R2 is independently selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 haloalkyl, C0-4 -alkylene, and R-C0-4-C-alkylene (O) -, in which R is selected from the group that it consists of hydroxyl, C1-4 alkoxy, amino, C1-4amino alkyl, C3-6 cycloalkyl, C4-6 heterocycloalkyl, and C5-6 heteroaryl, wherein C3-6 cycloalkyl, C4-6 heterocycloalkyl, and C5- heteroaryl 6 of R are each unsubstituted or substituted with 1-2 substituents independently selected from the group consisting of halo, amino, hydroxyl, C1-4 alkyl, C1-4 alkoxy, oxo, and C5-6 heteroaryl； and each R3 is independently selected from the group consisting of hydrogen and C1-4 alkyl； Ring A is selected from the group consisting of C6-10 aryl and C5-10 heteroaryl； Ring C is selected from the group consisting of C6-10 aryl, C5-10 heteroaryl, C5-7 cycloalkyl, C5-7 heterocycloalkyl, and fused bicyclyl comprising a C5-6 heterocycloalkyl fused to a phenyl； each R1 is independently selected from the group consisting of halo, cyano, amino, C1-4 alkyl, C1-4 alkoxy, halo- C1-4 alkyl, -C (O) NR7R8, -NHC (O) R11, phenyl, and C5-6 heteroaryl； wherein the phenyl and C5-6 heteroaryl of R1 are each unsubstituted or substituted with 1-2 substituents independently selected from the group consisting of C1-4 alkyl, amino, halo, and C1-4amino alkyl； R7 and R8 are each independently selected from hydrogen, C1-4 alkyl and C1-4 haloalkyl； R 11 is C 1-6 a
