Frederik Jan Rita Rombouts,Christopher John Love,Kristof Van Emelen,Sven Franciscus Anna Van Brandt,Tongfei Wu
申请号：
US11993237
公开号：
US08778919B2
申请日:
2006.06.26
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein m represents 1, n represents 1, Z represents N or C, in particular N —X1— represents C1-4alkyl, in particular methyl —X2— represents —C1-4alkyl- or —C1-4alkyl-NR7—, in particular propyl, -ethyl-NR7— or -propyl-NR7— —Y— represents —NR2—C1-6alkyl-CO—NR4—, -Het1-C1-6alkyl-CO—NR5— or -Het2-CO—NR6— and wherein the —C1-6alkyl-linker of —NR2—C1-6alkyl-CO—NR4— or -Het1-C1-6alkyl-CO—NR5— is optionally substituted with one or where possible two or more substituents selected from hydroxy, halo and phenyl R1 represents hydrogen, chloro, fluoro or bromo R2 represents —C1-4alkyl-, in particular ethyl or methyl R7 represents hydrogen R8 represents hydrogen R4, R5 and R6 represent hydrogen Het1 is selected from piperazinyl or piperidinyl, in particular -piperazinyl Het2 selected from pyrrolidinyl or piperidinyl, in particular pyrrolidinyl wherein said pyrrolidinyl is optionally substituted with hydroxy.
