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Derivatives of 1-benzyl-3-hydroxymethylindazole and its use in the treatment of diseases based on the expression of MCP-1 and CX3CR1
专利权人:
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
发明人:
GUGLIELMOTTI, Angelo,FURLOTTI, Guido,MANGANO, Giorgina,CAZZOLLA, Nicola
申请号:
ES09718101
公开号:
ES2570766T3
申请日:
2009.03.06
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
Compound of formula (I) ** Formula ** in which: A can be -X1- or -X1-O-X2-, in which X1 can be an alkyl group having 1 to 5 carbon atoms, substituted optionally 10 with one or more alkyl groups having 1 to 5 carbon atoms or one or more alkoxy groups having 1 to 3 carbon atoms, and X2 may be an alkyl group having 1 to 5 carbon atoms, optionally substituted with one or more alkyl groups having 1 to 5 carbon atoms, Y may be hydrogen, -OH, -N (R11) (R12), -N (R11) O (R12), in which R11 can be hydrogen, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 3 carbon atoms, or R11 together with R12 forms a 4- to 7-membered heterocycle, R12 can be hydrogen, a group alkyl having 1 to 5 carbon atoms, an alkoxy group having 1 to 3 carbon atoms, COR ', COOR', CON (R ') (R' ') with R' and R '', which can be the same or different from each other í, represented by hydrogen and an alkyl group having 1 to 5 carbon atoms, or R12 together with R11 forms a 4- to 7-membered heterocycle, R1 and R2, which may be the same or different from each other, may be hydrogen, an alkyl group having 1 to 5 carbon atoms, R3, R4 and R8, which may be the same or different from each other, may be hydrogen, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having from 1 to 3 carbon atoms, a halogen atom, -OH, -N (R ') (R' '), -N (R') COR '', -CN, -CONR'R '', -SO2NR 'R', -SO2R ', nitro and trifluoromethyl; with R 'and R' ', which may be the same or different from each other, represented by hydrogen and an alkyl group having 1 to 5 carbon atoms, R5 may be hydrogen, an alkyl group having 1 to 5 atoms of carbon, an alkoxy group having 1 to 3 carbon atoms, a halogen atom, -OH, -N (R ') (R' '), -N (R') COR '', nitro and trifluoromethyl, or R5, together with one of R6 and R7, forms a ring having 5 or 6 carbon atoms; with R 'and R' ', which may be the same or different from each other, represented by hydrogen and an alkyl group having 1 to 5 carbon atoms, R6 and R7, which may be the sam
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