您的位置: 首页 > 农业专利 > 详情页

Derivatives of 1-benzyl-3-hydroxymethylindazole and its use in the treatment of diseases based on the expression of MCP-1, CX3CR1
专利权人:
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
发明人:
GUGLIELMOTTI, Angelo,FURLOTTI, Guido,MANGANO, Giorgina,CAZZOLLA, Nicola,GAROFALO, Barbara
申请号:
ES09718467
公开号:
ES2569330T3
申请日:
2009.03.05
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
Compound of formula (I) ** Formula ** in which: A can be -X1- or -X1-OC (R9) (R10) -, in which X1 can be an alkyl group having 1 to 5 atoms carbon, optionally substituted with one or more alkyl groups having 1 to 5 carbon atoms or one or more alkoxy groups having 1 to 3 carbon atoms, and R9 and R10, which may be the same or different from each other, they can be hydrogen, an alkyl group having 1 to 5 carbon atoms or an alkoxy group having 1 to 3 carbon atoms, Y can be N (R11) (R12), N (R13) O (R14), N (R13) N (R14) (R15), N (R13) -X2-N (R14) (R15), N (R13) -X2-CO-X3, where R11 can be hydrogen, an alkyl group that it has 1 to 5 carbon atoms, an alkoxy group having 1 to 3 carbon atoms, or R11, together with R12, forms a 4- to 7-membered heterocycle, R12 can be hydrogen, an alkyl group having 1 at 5 carbon atoms, an alkoxy group having 1 to 3 carbon atoms, COR ', COO R ', CON (R') (R ''), with R 'and R' ', which may be the same or different from each other, represented by hydrogen and an alkyl group having 1 to 5 carbon atoms, or R12 , together with R11, forms a 4- to 7-membered heterocycle, R13 and R15, which may be the same or different from each other, may be hydrogen, an alkyl group having 1 to 5 carbon atoms or an alkoxy group having 1 to 3 carbon atoms, R14 may be hydrogen, an alkyl group having 1 to 5 carbon atoms, COR ', COOR', CON (R ') (R' '), with R' and R '', which may be the same or different from each other, represented by hydrogen and an alkyl group having 1 to 5 carbon atoms, X2 may be an alkyl group having 1 to 5 carbon atoms, optionally substituted with one or more alkyl groups having 1 to 5 carbon atoms or one or more alkoxy groups having 1 to 3 carbon atoms, X3 may be OH, NH2, NHOH or NHNH2, R1 and R2, which may be the same or different from each other, they can be hydrogen, an alkyl group having 1 to 5 carbon atoms or an alkoxy group having 1 to 3 carbon atoms, R3, R4 and R8, which can be the same or different from each other, they can be hydrogen,
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充