A compound of formula I ** Formula ** in which: R1 is CO2R5 or CONR6R7； R2 is pyridinyl, pyrazinyl, pyrimidinyl or pyridazinyl, and is substituted with 0-1 substituents selected from the group consisting of (R5) 2N, R12 , COR13 and SO2R14； or R2 is phenyl and is substituted with 0-2 substituents selected from halo, alkyl, alkoxy and haloalkoxy and is substituted with 0-1 substituents selected from the group consisting of (R5) 2N, ((R5) 2N ) alkyl (R5) N, (R12) alkyl (R5) N, alkylCON (R5), cycloalkylCON (R5), (methyl) oxadiazolyl, ((R5) 2N) alkoxy, (R12) alkoxy, R1210, ((R5) 2N) alkyl, (R12) alkyl, COR13, (alkylSO2) alkyl and SO2R14； or R2 is indolyl, indazolyl, benzimidazolyl, benzotriazolyl, pyrrolopyridinyl, benzoxazolyl, benzothiazolyl, and is substituted with 0-2 substituents selected from halo, alkyl, haloalkyl, nitro, cyano, alkoxy and haloalkoxy； or R2 is benzodioxolyl or dihydrobenzodioxynil, and is substituted with 0-2 substituents selected from halo and alkyl or； R3 is hydrogen, halo, alkyl, alkenyl, hydroxy, benzyloxy or alkoxy； R4 is cycloalkyl； R5 is hydrogen or alkyl； R6 is hydrogen, alkyl, alkylSO2, cycloalkylSO2, haloalkylSO2, (R9) (R10) NSO2 or (R11 ) SO2； R7 is hydrogen or alkyl； R8 is hydrogen, alkyl, cycloalkyl, (cycloalkyl) alkyl, alkylcarbonyl, cycloalkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, alkylSO2, cycloalkylSO2, haloalkylSO2, aminocarbonyl, (alkylamino) carbonyl, (dialkylamino) carbonyl, benzyl benzyloxycarbonyl or pyridinyl； R9 is hydrogen or alkyl； R10 is hydrogen or alkyl； R11 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N-alkylpiperazinyl, morpholinyl, thiomorpholinyl, homomorpholinyl homopiperidinilou； R12 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl , homopiperidinyl or homomorpholinyl, and is substituted with 0-3 substituents selected from oxo and alkyl； R13 is hydroxy, alkoxy, amino, alkylamino, dialkylamino, azetidin yl, pyrrolidinyl, piperidinyl, hydroxypiperidinyl, piperazin
