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New pyrrolopyrimidine compounds as protein kinase inhibitors
专利权人:
Inc.;Acea Biosciences
发明人:
XU, Xiao,WANG, Xiaobo,MAO, Long,ZHAO, Li,XI, Biao
申请号:
ES13745491
公开号:
ES2618007T3
申请日:
2013.07.11
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of Formula (VIII): ** Formula ** in which X1 is O, NH, S, CH2 or CF2; R1 and R2 are independently selected from hydrogen, halo, C1-6 alkyl and C1-6 haloalkyl; R3 is selected from halo, hydroxyl, C1-6 alkyl, C1-6 alkoxy, cyano and nitro; n is a number from zero to 4; R4 is selected from hydrogen, C1-6 alkyl, C3-7 cycloalkyl and -NR22R23; wherein the alkyl or cycloalkyl is not substituted or is substituted with hydroxyl or amino; and each of R22 and R23 is independently selected from hydrogen and C1-6 alkyl or R22 and R23 may be linked to form a 3 to 10 membered ring; R5 is selected from hydrogen and C1-6 alkyl; R 6 is selected from hydrogen, halo, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, hydroxy, cyano and nitro; R7 is selected from hydrogen, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, hydroxyl, cyano and nitro; R8 is selected from hydrogen, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, hydroxyl, cyano and nitro; Q is CR9 or N; where R9 is selected from hydrogen, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, hydroxyl, cyano and nitro; R11 is selected from hydrogen and C1-6 alkyl; R12 is selected from hydrogen and C1-6 alkyl; R13 is selected from hydrogen, C1-6 alkyl, C1-6 acyl, SO2-C1-6 alkyl, C3-7 cycloalkyl and C6-20 aryl, wherein each alkyl or aryl is not substituted or substituted with hydroxyl, C1-6 alkoxy or halo; and -NR18R19 is ** Formula ** wherein R10 is selected from hydrogen and C1-6 alkyl; R15 is unsubstituted methyl or is C2-4 alkyl unsubstituted or substituted with hydroxy, methoxy or halo; and m is 1 or 2; or is (b) where R19 and R9 taken together form a 5- or 6-membered heteroaryl ring optionally substituted with C1-6 alkyl that is unsubstituted or substituted with amino, hydroxyl or halo; and R18 is hydrogen or C1-6 alkyl or is absent to satisfy the valence of the heteroaryl ring; with the proviso that neither R6 nor R7 is methoxy when -NR18R19 is ** Formula ** o
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