KING-UNDERWOOD, JOHN,ITO, KAZUHIRO,MURRAY, PETER JOHN,HARDY, GEORGE,BROOKFIELD, FREDERICK ARTHUR,BROWN, CHRISTOPHER JOHN
申请号：
ES10771416
公开号：
ES2477270T3
申请日:
2010.10.19
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula (I) in which R1 is H, a saturated or unsaturated, branched or unbranched C1-15 alkyl chain, in which one or more carbons are optionally substituted or substituted by a heteroatom selected from O, N, S (O) p, wherein said chain is optionally substituted with one or more groups independently selected from oxo, halogen, an aryl group, a heteroaryl group, a carbocyclyl group or a heterocyclyl group, each aryl, heteroaryl, carbocyclyl group having or heterocyclyl: 0 to 3 substituents selected from halogen, -hydroxy, -C1-6 alkyl, -C1-6 alkoxy, -C2-3 -alkoxy-C1-3 alkyl, -C2-3-O-alkyl C1-3, -C1-3 hydroxyalkyl, -C1-6 haloalkyl, amino, -mono-C1-4alkyl- or -C2-8 -alkyl-alkyl, -mono-C1-4 acyl- or -C2 alkyl -8-amino, -C0-6-S (O) p-C1-6 alkyl, -C0-6-S-alkyl (O) pNR6R7, -C0-6-NR8-C0-6S alkyl (O) C1-6 alkyl, -C0-6-C (O) alkyl C0-6 alkyl, -NR8C0-6-C (O) alkyl NR6 R7, -NR8 C0-6-C (O) C0-6 alkyl, -C0-6-C alkyl (O) NR6R7, and -C0-6-C (O) C1-6 alkyl； and / or an aryl, heterocyclyl or carbocyclyl； X is C6-10 aryl or C5-9 heteroaryl, each substituted with R2a and with R2b, in which R2a is selected from hydrogen, -C1-3alkyl, halo, hydroxyl, cyano, -C1 -haloalkyl 3, -C1-3alkoxy, -C2-3-O-C1-3alkyl, -C2-3-O -C1-3alkyl, -C1-3 hydroxyalkyl, -C0-6alkyl S (O) C1-3alkyl, -C0-6- S alkyl (O) pNR6R7, -C0-6-NR8 alkyl C0-6-S (O) C1-6 alkyl, -C0-6-C alkyl (O) OH, -C0-6-C alkyl (O) O-C1-6 alkyl, -NR8C0-6-C alkyl (O) NR6R7, -NR8-C0-6-C alkyl (O) C1 alkyl -6, -C0-6-C (O) NR6R7 alkyl and -C0-6- C (O) -C 1-6 alkyl； and R2b is selected from hydrogen, C1-3 alkyl, halo, hydroxyl, cyano, C1-3 haloalkyl, C1-3 alkoxy, and C0-6-S (O) alkyl-C1-alkyl 3； R3a is hydroxyl； R3b is selected from hydrogen, hydroxyl, halo, cyano, C1-3 haloalkyl, C1-3 hydroxyalkyl, C1-3 alkoxy, and -S (O) C1-3 alkyl； R4 is hydrogen or C1-3alkyl； R5 is hydrogen or C1-3alkyl； R6 is hydrogen or -C 1-6 alkyl； R7 is hydrogen or -C 1-6 alkyl； R8 is hydrogen or -C 1-6 alkyl； p is 0 or an integer of 1 or 2； q is 0 or an integer
