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New derivatives of phthalacinonepyrrolopyrimidinecarboxamide
专利权人:
Takeda GmbH
发明人:
STENGEL, Thomas,MAIER, Thomas,MANN, Alexander,STADLWIESER, Josef,FLOCKERZI, Dieter,PAHL, Andreas,BENEDIKTUS, Ewald,HESSMANN, Manuela,KANACHER, Tobias,HUSSONG, Ragna,ZITT, Christof,HOLST, Hans Christof
申请号:
ES12728453
公开号:
ES2564882T3
申请日:
2012.06.12
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound of formula (1) ** Formula ** wherein R1 represents a phenyl derivative of formulas (a) or (b) ** Formula ** wherein R2 is predominantly 1-4C alkoxy or 1-4C alkoxy With fluorine, R3 is alkoxy 1-4C, cycloalkoxy 3-5C, cycloalkoxy (3-5C) -methoxy or alkoxy 1-4C predominantly or completely substituted with fluorine, R4 is alkoxy 1-4C or alkoxy 1-4C predominantly or completely substituted with fluorine, R5 is 1-4C alkyl, R6 is hydrogen or 1-4C alkyl or where R5 and R6 together and with the inclusion of the two carbon atoms, to which they are attached, form a hydrocarbon ring of 5, 6 or 7 members spiro-connected, optionally interrupted by an oxygen or sulfur atom, R7 is hydrogen, R8 is 1-4C alkyl, or R7 and R8 together form a 3C to 5C alkylene group, R9 is hydrogen or 1-4C alkyl , or where R8 and R9 together and with the inclusion of the carbon atom, to which they are attached, form a hydrocarbon ring of 5, 6 or 7 m bros connected in a spiro form, m is 1 or 2, R10 is independently of each other hydrogen, cycloalkyl 5-7C, alkyl 1-6C, -CH (CH3) -R11 or -CH2- R12, where R11 is unsubstituted phenyl or hydroxyl, R12 is hydroxyl, 5-7C cycloalkyl, -N- (1-2C alkyl) 2, -CH2-S- (1-2C alkyl), benzyl, unsubstituted phenyl, R13 substituted phenyl, R13 substituted phenyl and R14, wherein R13 is halogen, 1-4C alkoxy, 1-6C alkyl, fluoroalkyl 1-4C, hydroxyl, phenyl, -C (O) NH2, -CN, 2- oxoacetidin-1-yl or 2-oxopyrrolidine- 1-yl, R14 is halogen, 1-4C alkoxy, 1-6C alkyl, 1-4C fluoroalkyl, hydroxyl, phenyl, -C (O) NH2 or -CN, or R12 is selected from imidazol-2-yl, imidazole- 4-yl, pyrazol-1-yl, thiophene-2-yl, thiophene-3-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, pyridin-2-yl, pyridin-3- ilo, pyridin-4-yl, indole-2-yl, indole-3-yl, 1-methyl-indole-2-yl or 1-methylindole-3-yl, or R12 is -CH2-C (O) -R15 , wherein R15 is hydroxy, -N (R16) 2, piperidin-1-yl, pyrrolidin-1-yl or benzyloxy, wherein R16 is independently of each other hydrogen or 1-4C alkyl, R17 is hydrogen or methyl, R
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