EUN YOUNG BYUN,SEUNG AH JUN,YOUNG GIL AHN,KWEE HYUN SUH,IN HWAN BAE,JUNG BEOM SON,SANG MI HAN,EUN JOO KWAK,HO SEOK KIM,JI YOUNG SONG
申请号：
ARP120105010
公开号：
AR089489A1
申请日:
2012.12.27
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Have Inhibitory activity to the kinase Proteins, and a Pharmaceutical composition that comprises for the Prevention and Treatment of Diseases of abnormal cell growth.Claim 1: a Derivative of thieno [3,2-d] pyrimidine of formula (1) or one of its Salts are acceptable from the standpoint of Pharmaceuticals, where a is c u2081 u208b u2086 c u2083 u208b u2086 Hydrogen, alkyl, cycloalkyl, heterocicloalquilo 3 to 6 members, aryl or heteroaryl c u2086 u208b u2081 u2080 5 to 10 Member, wherein Said aryl or heteroaryl is reduced with Hydrogen or optionally substituted； W is o, S, S (o),S (o) u2082, NH, - - or nhnh heterocicloalquilo 3 to 6 members； X and y are each independently CH o n； Z is Hydrogen, alkyl or c u2081 u208b u2083 nr u00b3r u2074, wherein Said r u00b3 and r u2074 are each independently Hydrogen or - alkyl c u2081 u208b u2086 (ch u2082) Q - B -, B represents nr u2075r u2076, alkoxy C u2081 u208b u2086, cycloalkyl or c u2083 u208b u2086 heterocicloalquilo 3 to 6 members； r u00b9 is Hydrogen, halogen, alkyl or alkoxy c u2081 u208b u2083 c u2081 u208b u2083,Where the alkyl or alkoxy is not replaced or substituted with one or more Halogen Atoms； R u00b2 is Hydrogen, halogen, cf u2083 no u2082 -, -, - Oh, - CN, c u2081 u208b u2086 c u2081 u208b u2086 alkyl, alkoxy, alquenilo c u2082 u208b u2084, alquinilo c u2082 u208b u2084, - nr u2077r u2078 nhso u2082r u2079 so u2082r u00b9 u2070, -, -, - C (o) r u00b9 u00b9, R u00b9 u00b2 - NHC (OR), (OR) - NHC or u00b9 u00b3, - S (o) r u00b9 u2074 c u2083 u208b u2086 heterocicloalquilo, cycloalkyl, aryl 5 to 10 members, c u2086 u208b u2081 u2080, ariloxi c u2086 u208b u2081 u2080,Heteroaryl 5 to 10 members or heteroariloxi 3 to 6 members, where the R u00b2 is connected to by - (ch u2082) u209a - or substituted alkyl c u2081 u208b u2084, alquinilo c u2082 u208b u2084, alquilcarbonilo c u2081 u208b u2084 or one or more Halogen Atoms； r u2075, r u2076, r u2077, r u2078, r u2079, r u00b9 u2070, r u00b9 u00b9, r u00b9 u00b2, r u0
