The present invention relates to the compound with logical formula (I) or its physiologically functional derivative,Solvate or salt,Wherein A be key,Optionally by one or more R " as herein defined alkyl replaced or alkoxy,*-N(R” ’)CO-,*-CON(R” ’)-,*-N(R”’)CON(R” ’)-,-S-,-SO-,*-N(R” ’)-,*-N(R” ’)CO-,*-CON(R” ’)-,-CO-,*-COO-,*-OOC-,*-SO2N(R” ’)-,-SO2,Or *-N (R " ')-SO2-,Wherein R " ' is as herein defined and * is refered in particular to and the point of X attachment； X be aryl,Naphthenic base,Aralkyl,Heterocycle or heteroaryl,It can be replaced by one or more RX described further herein； L be key or *-N (RN) CO-,*-CON(RN)-,*-N(RN)-,*-C=N (RN)-,*-N (RN)-alkyl-,*-alkyl-N (RN)-,*-N(RN)CON(RN)-,*-CO-,*-SO2-,Alkyl,*-alkyl-O- alkyl-,*-NCO-CH=CH-,*-CH=CH-CONH-,*-SO2N(RN)-,*-N(RN)SO2-,Or heterocycle,The point that wherein * is refered in particular to and X is attached； Y be H,Alkyl,Aryl,Aralkyl,Naphthenic base,Heterocycle or heteroaryl,It can be replaced by one or more RY described further herein； And R and RN are described further herein； And they as medicament purposes,Including their Pharmaceutical composition,The method for needing to give their medical conditions is treated or prevented,And their purposes in the medicament that production treats or prevents medical conditions with what,The medical conditions especially autoimmune inflammatory disease,CNS disorder,Sleep disturbance,Or the proliferative diseases including cancer. The invention further relates to the specific methods that the compound is prepared with what.本發明涉及具有通式(I)的化合物或其生理學上功能性的衍生物、溶劑化物或鹽，其中A是鍵、可任選地被一個或多個如本文所定義的R”取代的烷基或烷氧基、*‑N(R” ’)CO‑、*‑CON(R” ’)‑、*‑N(R”’)CON(R” ’)‑、‑S‑、‑SO‑、*‑N(R” ’)‑、*‑N(R” ’)CO‑、*‑CON(R” ’)‑、‑CO‑、*‑COO‑、*‑OOC‑、*‑SO2N(R” ’)‑、‑SO2、或*‑N(R” ’)‑SO2‑，其中R” ’是如本文所定義的並且*特指與X附接的點；X是芳基、環烷基、芳烷基、雜環基或雜芳基，其可以被一個或多個本文進一步描述的RX取代；L是鍵或*‑N(RN)CO‑、*‑CON(RN)‑、*‑N(RN)‑、*‑C＝N(RN)‑、*‑N(RN)‑烷基‑、*‑烷基‑N(RN)‑、*‑N(RN)CON(RN)‑、*‑CO‑、*‑SO2‑、烷基、*‑烷基‑O‑烷基‑、*‑NCO‑CH＝CH‑、*‑CH＝CH‑CONH‑、*‑SO2N(RN)‑、*‑N(RN)SO2‑、或雜環基，其中
