This application relates to the preparation, The therapeutic uses and Compound degraders inhibitors and estrogen Receptors, especially useful in the treatment of cancer.Claim 1: a compound of the formula [1], where: r u00b9 and R u00b2 independently represent a hydrogen Atom or a deuterium Atom； r u00b3 represents a hydrogen Atom, a Group - COOH,An - Oh Group and EPO Group (- Oh) u2082； r u2074 represents a hydrogen Atom or a Fluorine Atom； r u2075 represents a hydrogen Atom or an - Oh Group； wherein: at least one of r u00b3 or r u2075 is different from a u00e1tOmo Hydrogen； when r u00b3 represents a Group - COOH, - Oh Group and EPO Group (- Oh) u2082, then r u2075 represents a hydrogen Atom； when r u2075 represents an - Oh Group.And then r u00b3 r u2074 represent Hydrogen Atoms； r u2076 is selected from a group comprising a phenyl or heteroaryl Group 3 to 9 carbon Atoms and comprises 1 to 3 heteroatoms selectedTwo independently between Oxygen, nitrogen and sulfurWhile these groups without replacing or heteroaryl phenyl substituted with 1 to 3 substituents selected from an alkyl group c u2081 u208b u2086 independently, without replacing or substituted with one or more untoVolumes of a Halogen Atom； Fluorine； An - Oh Group； a Group c u2081 u208b u2086 without replacing or alkoxy substituted with one or more Fluorine Atoms； a cyano Group； a group of Sulfur substituted with Fluorine Atoms or 5 gRupos c u2081 u208b u2086 alkyl substituted with two or more Atoms of Fluorine alkyl sulfonyl Group； a c u2081 u208b u2086 where the alkyl group c u2081 u208b u2086 is replaced without replacing or with two or more Fluorine Atoms； a group SIn 3 groups substituted with alkyl Amine Group c u2081 u208b u2086； without a substitute or substituted with one or more alkyl groups c u2081 u208b u2086； amide Group without a substitute or substituted with one or more alkyl groups c u2081 u208b u2086；Group heterocicloalquilo saturated or partially saturated, which comprises 3 to 5 Carbon
