LINDA N. CASILLAS,PAMELA A. HAILE,ROBERT W. JR. MARQUIS,GREN WANG
申请号：
ARP130103247
公开号：
AR092529A1
申请日:
2013.09.11
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
A compound of the formula aminoquinazolina has: (1) where X is selected from the group of formulas (2)； r u00b9 u1d43 and r u00b9 u1d47 are each, independently, h,C u2081 u208b u2084 ch u2082oco u2082 alkyl or alkyl c u2081 u208b u2084； or r u00b9 u1d43 and r u00b9 u1d47 together represent u2082 (ch u2082) or (ch u2082) u2083； r u00b2 u1d43, r u00b2 u1d47, r u00b3 u1d43 and r u00b3 u1d47 are each independently H or alkyl c u2081 u208b u2084,Where the alkyl c u2081 u208b u2084 is optionally substituted with alkyl Carbon c u2081 u208b u2084； or r u00b2 u1d43 and r u00b2 u1d47 represent Together (by Land. Ch u2082), (ch u2082) u2085 (ch u2082) u2082o ( u2082, ch u2082)(ch u2082) u2082nh (ch u2082) u2082 or (ch u2082) u2082n (ch u2083) (ch u2082 u2082)； or r u00b3 u1d43 and r u00b3 u1d47 represent Together (by Land. Ch u2082), (ch u2082) u2085 (ch u2082) u2082o ( u2082, ch u2082)(ch u2082) u2082nh (ch u2082) u2082 or (ch u2082) u2082n (ch u2083) (ch u2082 u2082)； or r u00b2 u1d47 and r u00b3 u1d47 together represent u2082 (ch u2082) or (ch u2082) u2083； r u2074 is Oh or nh u2082； r u2075 c u2081 u208b u2086 is alkyl, o-alkyl c u2081 u208b u2084, nr u2076r u2077 or heterocicloalquilo 5 or 6 members.Where the alkyl c u2081 u208b u2086 is replaced with Oh, op (= o) (OH) u2082, nh u2082 nhco - alkyl or c u2081 u208b u2084, where the alkyl group c u2081 u208b u2084,The alkyl group of the alkyl c u2081 u208b u2084 nhco c u2081 u208b u2084 is optionally substituted with nh u2082, and wherein Said heterocicloalquilo 5 or 6 members are optionally replaced,Once or twice, independently, with c u2081 u208b u2084 oxo alkyl, or a heterocicloalquilo 5 or 6 additional members； and r u2076 and r u2077 are each, independently,H or alkyl c u2081 u208b u2084； or a Salt thereof.Pharmaceutical composition containing same and use of the compound for the preparation of a Medicine applied in the treatment of a disease or Disorder involving the inhibition ofRIP2 Kinase.Un compue
