This table refers to the compounds in formula (1),2. It is opposite to the recipient of citoquine 2 (CCR2) and / or 5 (CCR5) induced by chemistry；Drug synthesis and method of use. Claim 1: a formula compound (1), wherein one of the two symbols represents 8315； - 8315； - 8315； - 8315； - 8315； - 8315； - 8315； independently represents a simple link and the other represents two links； R1,R3 stands for independent representation of each other,H or c83218331 / 832626 linear or branched asphalt；X is selected from the group of hetx - (ch832222) qhetx, n8310a hetx, in which hetx is related to the adjacent group by N atom in its ring or N atom selected from hetx-n8310a；Ar-NR⁶,1. In Act No. 8310, it is associated with adjacent groups or groups listed in Act No. 8310；where N * R⁶ is linked to the adjacent CO group； Q denotes a saturated, unsaturated or aromatic ring of 5 or 6 members which optionally contains 1 or 2 nitrogen atoms and which is optionally substituted with 1 or 2 of Rᵇ and Rᶜ or alternatively QX together denote a fused bicyclic system, which contains an N atom linked to the adjacent CO group, which may contain 1 to 3 additional heteroatoms independently selected from N, O, S and / or a CO group and which may be substituted with 1 or 2 of Rᵇ and Rᶜ ；And denotes a single bond, a branched or linear C₁₋₆ alkylene or a C₃₋₇ cyclic alkylene,Among them, in this periodic, linear or branched tar, one to five H atoms can be replaced by or8310 independently；Hal o CN； R: H, CYC, Hal, het, AR, - (ch832222) qcohet, - (ch832222) qcoar, - (ch832222) qcocyc, - (ch832222) qcoc222； r8310；Or8310；R74919 represents cf8323；OCF83223,Hal, CN, a linear or branched alkyl C₁₋₆ or when Q denotes a saturated, unsaturated or aromatic ring of 5 or 6 members which optionally contains 1 or 2 nitrogen atoms and which is substituted with 1 or 2 of Rᵇ and Rᶜ,R74919 also represents h； r74955 represents Hal, r8310；CN, CF₃ or OCF₃；Rᶜ denotes a linear or branched C₁₋₆ alkyl,Or8310；R749669 is linear or
