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Macrocyclic Pyridazinone Derivatives
专利权人:
Merck Patent GmbH
发明人:
JORAND-LEBRUN, Catherine,KULKARNI, Santosh,CHRISTMANN-FRANCK, Serge
申请号:
ES14706474
公开号:
ES2639717T3
申请日:
2014.02.07
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula (I) ** Formula ** where R1, R3 each independently indicate H, (CH2) pCON (R5) 2, OA, Hal, COOH, COOA, (CH2) pNHCOA, (CH2 ) pHet1, (CH2) pNR2R5 or OH; R2 indicates H or linear or branched alkyl with 1, 2 or 3 C atoms, where one or two H atoms of the alkyl group may be substituted by OR6, NR5R6, NHCOR5, CONR5R6; R4 indicates H or methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl or tert-butyl, pentyl, 1-, 2- or 3- methylbutyl, 1,1-, 1,2- or 2,2 -dimethylpropyl, 1-ethylpropyl, hexyl, 1-, 2-, 3- or 4-methylpentyl, 1,1-, 1,2-, 1,3-, 2,2-, 2,3- or 3,3 -dimethylbutyl, 1- or 2-ethylbutyl, 1-ethyl-1-methylpropyl, 1-ethyl-2-methylpropyl, 1,1,2- or 1,2,2-trimethylpropyl, trifluoromethyl; R5 indicates H or linear or branched alkyl with 1, 2 or 3 C atoms; R6 indicates H or linear or branched alkyl with 1, 2 or 3 C atoms; Z is absent or indicates Ar-diyl or Het-diyl; L indicates (CH2) n where one or two CH2 groups can be substituted by O and / or a group CH>; = CH, and / or where one or two H atoms can be substituted by OR2, NR2R5 or Het1; Ar-diyl indicates 1,2-, 1,3- or 1,4-phenylene optionally substituted by 1 to 5 groups independently selected from Hal, CN, -CF3, -OCF3, OH, OA, SO2-A, COOH, COOA, -CO-A, O-phenyl, SO2-phenyl, SO2-CF3, Het2 and / or A; Het-diyl indicates an unsaturated, saturated or aromatic heterocycle of 5 or 6 atoms with 1 to 2 atoms of N, O and / or S, which may not be substituted or be mono, di or trisubstituted by Hal, CN, -CF3, -OCF3, OA, SO2-A, COOH, COOA, -CO-A, O-phenyl, SO2-phenyl, SO2-CF3, Het2 and / or A; A indicates an unbranched or branched alkyl with 1 to 10 C atoms, in which 1 to 5 H atoms can be substituted by F and / or in which one or two adjacent CH2 groups can be substituted by O; Het1 indicates morpholinyl, piperidinyl or pyrrolidinyl; Het2 indicates morpholinyl, piperidinyl or pyrrolidinyl; Hal indicates F, Cl, Br, I; n indicates 1, 2, 3, 4, 5 or 6; p indicates 0, 1 or 2; and pharmaceutically useful taut
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