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Heteroaryl- [1,8] naphthyridine derivatives
专利权人:
Merck Patent GmbH
发明人:
JONCZYK, Alfred,DORSCH, Dieter,HOELZEMANN, Guenter,AMENDT, Christiane,ZENKE, Frank
申请号:
ES10794897
公开号:
ES2667049T3
申请日:
2010.12.17
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Compounds of formula (I) ** Formula ** where W1, W3 independently indicate each other N, NO or CR3; W5, W6 independently indicate each other N, NO or CR4; with the proviso that at least one of W1, W3, W5 or W6 indicates N; R1 indicates a monocyclic carboaryl with 5-8 atoms of C, Het1 or a monocyclic heteroaryl with 2-7 atoms of C and 1-4 atoms of N, O and / or S, each of which may be substituted by at least a substituent selected from the group of Y, Hal, CN, OY; R2 indicates Ar, Het1 or Het², each of which may be substituted by R5; R3, R4 independently indicate each other H, NYY, -NY-COY, A, OY or COOA; R2, R3 together also indicate Alq with the proviso that R2 and at most one R3 adjacent to R2 are together; R5 indicates Hal, A, - (CYY) n-OY, - (CYY) n-NYY, (CYY) n-Het³, SY, NO2, CN, COOY, -CO-NYY, -NY-COA, - NY- SO2A, -SO2-NYY, S (O) mA, -CO-Het³, -O (CYY) n-NYY, -O (CYY) n-Het³, -NH-COOA, -NH-CO-NYY, -NH -COO- (CYY) n-NYY, -NH-COO- (CYY) n-Het³, -NH-CO-NH- (CYY) n-NYY, -NH-CO-NH (CYY) n-Het³, - OCO-NH- (CYY) n-NYY, -OCO-NH- (CYY) n-Het³, CHO, COA,>; = S,>; = NY,>; = O, Alq-OH, -CO-NY- (CYY ) n- NYY, -CO-NY-Het³ or -SO2-Het³; Y indicates H or A; A indicates unbranched or branched alkyl with 1-10 C atoms, in which 1-7 H atoms can be independently substituted from each other by Hal and / or in which one or two CH2 groups can be independently substituted from each other by an O, S, SO, SO2, a group -CY>; = CY- and / or a group -C≡C-; Alq indicates alkylene, alkenyl or unbranched alkynyl with 2-5 C atoms, in which 1-2 H atoms can be independently substituted from each other by R5 and / or in which 1-4 C atoms can be independently substituted each other for N, O and / or S; Ar indicates a saturated, unsaturated or aromatic monocyclic or bicyclic carbocycle with 6-10 C atoms; Het1 indicates a saturated, unsaturated mono, bi or tricyclic heterocycle of 2-19 C atoms and 1-5 N, O and / or S atoms; Het² indicates a mono, bi or tricyclic heteroaryl with 2-19 C atoms
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