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DERIVES D'OXADIAZOLE
专利权人:
MERCK SERONO S.A.
发明人:
QUATTROPANI, ANNA,MONTAGNE, CYRIL,SAUER, WOLFGANG,CROSIGNANI, STEFANO,BOMBRUN, AGNES
申请号:
CA2755928
公开号:
CA2755928C
申请日:
2010.03.29
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
The invention relates to compounds of formula (AC):(see formula AC)whereinR1, R2 independently from one another denote H, CF3, OCF3, CN, NO2,or OH,Y COOH,Q denotes (CH2)X(CH2).X is ¨NA-,W denotes CH,G1, G2 independently from one another denote H, Hal, or CH3,R a is CH3, CH2CH3, F, Br, CI, or CF3,R b is CF3,A denotes a linear or branched alkyl having 1 to 6 C-atoms(preferably 1to 3 carbon atoms), wherein one H-atom may be replaced by Hal, OH,COOR3, CN, or N(R3)2 and wherein one or more CH2-group may bereplaced by O, -NR4-, -NR4CO-, -CO-, S, -CH=CH- or -C.ident.C-groups, andR3 denotes H or a linear or branched alkyl having 1 to 6 C-atoms,or pharmaceutically acceptable solvates, tautomers, salts, stereoisomersthereof, or mixturesthereof in all ratios. The compounds are useful e.g. in the treatment ofautoimmunedisorders, such as multiple sclerosis.
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