ВЕЛА ЭРНАНДЕС Хосе Мигель (ES),САМАНИЛЬО-КАСТАНЕДО Даниэль (ES)
申请号：
RU2012137506/15
公开号：
RU2012137506A
申请日:
2011.02.04
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A combination for simultaneous, separate or sequential administration comprising at least one sigma ligand of formula (I), or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof, and at least one opioid or opiate intended for the prevention and / or treatment of pain developing as a consequence of surgical intervention where R is selected from the group formed by hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted, aromatic or non-aromatic heterocyclyl, substituted or unsubstituted heterocyclylalkyl, -COR, -C (O) OR, -C (O) NRR, -CH = NR, -CN, OR, -OC (O) R, -S (O) -R, -NRR, -NRC (O) R, -NO, -N = CRR or halogen R is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted, aromatic or non-aromatic heterocyclyl, substituted or unsubstituted heterocyclylalkyl, -COR, C (O) OR, -C (O) NRR, -CH = NR, -CN, -OR, -OC (O) R, -S (O) -R, -NRR, -NRC (O) R, NO, -N═CRR or halogen R and R are independently selected from the group formed by hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted, aromatic or non-aromatic heterocyclyl, substituted or unsubstituted heterocyclylalkyl substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted, aromatic or non-aromatic heterocyclyl, substituted or unsubstituted heterocyclylalkyl, -COR, -C (O) OR, -C (O) NRR,
