ГАЛЛАН Мишель (CA),ВИЛЛЬНЕВ Карин (CA),БОЛЬЕ Патрик (CA),РОБИШО Жоэль (CA),ЖЮТО Элен (CA),ГАРО Ив (CA),УОДДЕЛЛ Шерман Т. (US),КЕВИН Нэнси (US),ГУ Синь (US),ХЬЮБЕР Джоанн (US),САЛЬВАТОР Майкл Дж. Мл. (
申请号：
RU2012142832/04
公开号：
RU2012142832A
申请日:
2011.03.04
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. The compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R is selected from C (R) O, C (R) OR, COOR or CONRR； R and R are independently selected from H, halogen, OR, SR, SOR and NRR； R and R are independently selected from hydrogen, C-C1-6alkyl, cycloalkyl, alkenyl, cycloalkenyl and aryl, where alkyl, cycloalkyl, alkenyl, cycloalkenyl or aryl is optionally substituted with one or more of C-C1-6alkyl, -NRR, guanidine, -OR, OCONRR, COR, CONRR, CN , SOR, SOR, SONRR, F, Cl, Br, I or CF； or R and R, together with the atoms to which they are directly bonded, form a 4-5 membered heterocycle optionally substituted with one or more C-C1-6alkyl, - NRR, guanidine, -OR, OCONRR, COR, CONRR, CN, SOR, SOR, SONRR, F, Cl, Br, I or CF； Q is AryA or HetA； AryA is aryl optionally substituted with one or more of AryB, R optionally substituted AryB, C-C1-6alkyl, optionally substituted AryB, C-Salkenyl, optionally substituted AryB, or C-alkynyl, optionally substituted AryB； HetA is heteroaryl, optionally substituted with one or more of AryB, R, optionally substituted AryB, C- C1-6alkyl optionally substituted with AryB, C1-6alkenyl optionally substituted with AryB or C1-6alkynyl optionally substituted with AryB； AryB is ary l optionally substituted with C-C1-6alkyl or phenyl； R, R, R are independently selected from H and C-C1-6alkyl, where alkyl is optionally substituted with one or more of —OR, OCONRR, OCOR, COR, COR, CONRR, CN, SOR, SOR, SONRR, F, Cl, Br, I or CF； and R, R and R are independently selected from H and C-C1-6alkyl. 2. The compound according to claim 1, where R denotes CHOH, COOH or CONH. 3. A compound according to claim 1 or 2, wherein R and R are independently selected from H and OR. The compound according to claim 3, where R and R are independently selected from H, OH and OCH. 5. A compound according to claim 1, wherein R and R are H or C-C1-6alkyl, where the alkyl is optionally substituted with an amine, guanidine or —NRR. The compound accor
