ДЗЕ РИДЖЕНТС ОФ ДЗЕ ЮНИВЕРСИТИ ОФ КОЛОРАДО; Э БОДИ КОРПОРЕЙТ (US)
发明人:
ЛЮ Сюэдун (US),ФИЛЛИПС Эндрю Дж. (US),УНГЕРМАННОВА Дана (US),НАСВЕСЧУК Кристофер Г. (US),ЧЖАН Ган (US)
申请号：
RU2012157293/04
公开号：
RU2012157293A
申请日:
2011.05.26
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A compound of formula (I), A is aryl or heteroaryl optionally substituted with one or more groups selected from CC-alkyl, CC-cycloalkyl, CC-heterocycloalkyl, aryl, heteroaryl, halogen, hydroxyl, -CN, -COOH, -CF, -OCHF, -OR, -NRR, -NCORR, -CONRR Z is - (CH) SR R and R are independently H, CC-alkyl, CC-cycloalkyl, CC-heterocycloalkyl, or R and R together or one of R and R together with R forms CC-cycloalkyl or CC-heterocycloalkyl, wherein CC-alkyl, CC-cycloalkyl and CC-heterocycloalkyl are optionally substituted with one or more groups selected from C-cycloalkyl, CC-heterocycloalkyl, aryl, heteroaryl, halogen, hydroxyl, -CN, -COOH, -CF, -OCHF, -OR, -NRR, -NCORR, -CONRR R and R are independently H, CC-alkyl, CC-cycloalkyl, CC-heterocycloalkyl, or R and R together, or one of R and R together with R forms CC-cycloalkyl or CC-heterocycloalkyl, wherein CC-alkyl, CC-cycloalkyl and CC-heterocycloalkyl are optionally substituted with one or more groups selected from CC-alkyl, C-Ccycloalkyl, CC-heterocycloalkyl, aryl, heteroaryl, halogen, hydroxyl, -CN, -COOH, -CF, -OCHF, -OR, -NRR, -NCORR, -CONRR, -S (OR R and R are independently H, CC-alkyl, CC-cycloalkyl, CC -heterocycloalkyl, or R and R together, or one of R and R together with R form CC-cycloalkyl or CC-heterocycloalkyl, wherein CC-alkyl, CC-cycloalkyl, CC-heterocycloalkyl is optionally substituted with one or not ring groups selected from CC-alkyl, CC-cycloalkyl, CC-heterocycloalkyl, aryl, heteroaryl, halogen, hydroxyl, -CN, -COOH, -CF, -OCHF, -OR, -NRR, -NCORR, -CONRR R independently are H, F, CC-alkyl, CC-cycloalkyl,
