БРУКФИЛД Фредерик (GB),БЁРЧ Джейсон (US),ГОЛДСМИТ Ричард А. (US),ХУ Байхуа (US),ЛАУ Кевин Хон Луэн (US),МАККИННОН Колин Х. (GB),ОРТВАЙН Даниэль Фред (US),ПЭЙ Чжунхуа (US),У Гошэн (CN),ЮЕНЬ По-вай (US)
申请号：
RU2015106013
公开号：
RU2015106013A
申请日:
2013.08.09
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. The compound of formula (AA): or its stereoisomers or its pharmaceutically acceptable salt, in which: ring A represents a 5-7-membered cycloalkyl or 5-7-membered heterocyclyl； p is 0, 1, 2, 3, 4, 5, 6, 7 or 8； each R independently is a bond, hydrogen, CC-alkyl, CC-alkenyl, CC-alkynyl, CC-alkylene, CC-alkenylene, CC-alkynylene, halogen, —CN, —OR, —SR , -NRR, -CF, -CHF, -CHF, -OCF, -NO, -C (O) R, -C (O) OR, -C (O) NRR, -NRC (O) R, -S ( O) R, —NRS (O) R, —S (O) NRR, CC-cycloalkyl, 3-10 membered heterocyclyl or 6-10 membered aryl, with each R not being a bond and hydrogen independently independently possible replaced by groups th R or two R are joined together with the atoms to which they are attached to form CC alkylene, CC alkenylene, CC alkynylene, CC cycloalkyl, 3-10 membered heterocyclyl or 6-10 membered aryl, wherein said cycloalkyl , heterocyclyl and aryl are independently optionally substituted by an R group, or two R are connected together with the atom to which they are attached to form CC-cycloalkyl or a 3-10 membered heterocyclyl, wherein said cycloalkyl and heterocyclyl are independently possibly substituted by an R group； R is hydrogen, CC-alkylene, CC-alkenylene, CC-al nylene or 3-10 membered heterocycle, wherein said alkylene, alkenylene, alkynylene and heterocycle are independently optionally substituted with halogen, oxo, CC-alkyl, CC-alkenyl, CC-alkynyl, -OR, -SR, -NRR, -CN, —CF, —CHF, —CHF, —OCF, CC-cycloalkyl, 3-10 membered heterocyclyl or 6-10 membered aryl, and wherein said alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl and aryl are independently optionally substituted with R ； R is hydrogen, CC-cycloalkyl, 3-10 membered heterocyclyl or 6-10 membered aryl, wherein R is independently optionally substituted with R, or R when R is hydrogen； each R and R are independently hydrogen, C-C-alkyl, C-C-cycloalkyl, 3-6 membered heterocyclyl or phenyl, wherein1. Соединение формулы (АА):или его стереоизомеры или его фармацевтически приемлемая соль, в кот
