ХУД Джон (US),УОЛЛЭЙС Дэвид Марк (US),КС Сунил Кумар (US)
申请号：
RU2014144309
公开号：
RU2014144309A
申请日:
2013.03.13
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. The compound or a pharmaceutically acceptable salt thereof having a structure represented by formula I wherein R is heteroaryl-RR； R is selected from the group consisting of H, heteroaryl-R, heterocyclyl-R and aryl-R； R is selected from the group consisting of H, heterocyclyl-R, -NHC (= O) R, -NHSOR, -NRR and (C-alkyl) NRR； provided that R and R are not both H； R is 1-3 substituents each selected from the group consisting of H, C-alkyl, halide, -CF, -CN, -OR and amino； each R independently represents 1-4 substituents, each selected from the group consisting of H, C-alkyl, gal ohenide, -CF, -CN, -OR, -C (= O) R, amino and (C-alkyl) NRR； each R is independently 1-5 substituents selected, each, from the group consisting of H, C- alkyl, halide, CF, CN, OR, and amino； each R independently represents 1-5 substituents, each selected from the group consisting of H, C-alkyl, halide, —CF, —CN, —OR, amino, (C- alkyl) NHSOR, -NR (C-alkyl) NRR and (C-alkyl) NRR； R is 1-5 substituents selected each from the group consisting of H, C-alkyl, halide, -CF, -CN, - OR and amino； R are selected from the group consisting of C-alkyl, heteroaryl-R, heterocyclyl-R, aryl-R and CH-carbocytes kyla； R is selected from the group consisting of C-alkyl, heteroaryl-R, heterocyclyl-R, aryl-R and carbocyclyl-R； each R is independently selected from C-alkyl； each R is independently selected from the group consisting of H and C-alkyl； each R and R are optionally connected to form a five- or six-membered heterocyclyl； each R is independently selected from the group consisting of H and C-alkyl； R is 1-5 substituents selected, each from the group consisting of H, C-alkyl, halide, - CF, —CN, —OR, and amino； provided that Formula I is not a structure selected from the group consisting of from: 2. The compound of claim 1, wherein R1 is pyridine-RR.3. A compound according to claim 2, wherein R4 is pyridin-3-yl-RR. 4. Compounds1. Соединение или его фармацевтически приемлемая соль, имеющее структуру, представ
