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Amidoacridine derivatives useful as selective inhibitors of ubiquitin-specific protease 7
专利权人:
HYBRIGENICS S.A.
发明人:
LOPEZ, ROMAN,COLLAND, FRÉDÉRIC
申请号:
ES11701220
公开号:
ES2523383T3
申请日:
2011.01.17
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
Compound of formula (I): ** Formula ** in which: - i is an integer selected from 0, 1, 2, 3 or 4; - j is an integer selected from 0, 1, 2 or 3; - k is an integer selected from 0 or 1; - each Ri located in any available position of ring A is identical or different and is selected from halogen, alkyl, aryl, -alkylaryl, OR, NRR ', CN, CF3, COR, COOR, CONRR'; - each Rj located in any available position of ring C is identical or different and is selected from halogen, alkyl, aryl, -alkylaryl, OR, NRR ', CN, COR, COOR, CONRR'; - Rk is independently selected from halogen; - X is selected from H, alkyl, aryl, -alkylaryl, wherein said alkyl and / or aryl are optionally substituted by halogen, alkyl, CN, CF3, OR, NRR ', COR, COOR, CONRR'; - And is selected from: - (CHT ') pNRaRb in which · Ra and Rb, identical or different, are independently selected from H, alkyl, aryl or arylalkyl, wherein said aryl is optionally substituted by halogen, alkyl , CN, CF3,>; = O, OR, NRR ', COR, COOR, CONRR'; * or Ra and Rb together with the N atom to which an N is attached comprising a heterocycle of 5 to 7 links that may comprise one or two heteroatoms more selected from N, O or S, said heterocycle being optionally substituted by one or more of halogen; >; = O; I rent; -alkylaryl or aryl wherein said aryl is optionally substituted by halogen; CN; CF3; OR; NRR '; COR; COOR; CONRR '; · P is an integer selected from 0 to 6; - each T ', identical or different, is independently selected from H or alkyl; ** Formula **Compuesto de fórmula (I):**Fórmula** en la que: - i es un número entero seleccionado de entre 0, 1, 2, 3 o 4; - j es un número entero seleccionado de entre 0, 1, 2 o 3; - k es un número entero seleccionado de entre 0 o 1; - cada Ri situado en cualquier posición disponible del anillo A es idéntico o diferente y se selecciona 15 de entre halógeno, alquilo, arilo, -alquilarilo, OR, NRR', CN, CF3, COR, COOR, CONRR'; - cada Rj situado en cualquier posición disponible del anillo C es id
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