CYCLOPAMINE ANALOGUES AND METHODS OF USE THEREOF

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专利权人:

发明人:

申请号：

HK11111953.9

公开号：

HK1157758A

申请日:

2011.11.04

申请国别(地区):

HK

年份:

2012

代理人:

摘要：

The present invention provides compositions and methods for modulating smootheneddependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-offunction mutations. The compounds of the present invention are particularly useful in treating cancers.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/