Janardanannair, Somarajannair,Adams, Julian,Castro, Alfredo C.,Foley, Michael A.,Nevalainen, Marta,Tremblay, Martin,Porter, James R.
申请号：
AU2005280112
公开号：
AU2005280112B2
申请日:
2005.08.26
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention provides compositions and methods for modulating smootheneddependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-offunction mutations. The compounds of the present invention are particularly useful in treating cancers.
