ADAMS JULIAN U S A,CASTRO ALFREDO C U S A,FOLEY MICHAEL A U S A,JANARDANANNAIR SOMARAJANNAIR U S A,NEVALAINEN MARTA U S A,PORTER JAMES R U S A,TREMBLAY MARTIN U S A
申请号：
IN364/KOLNP/2012
公开号：
IN2012KN00364A
申请日:
2012.02.17
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
The present invention provides compositions and methods for modulating smootheneddependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of- function mutations. The compounds of the present invention are particularly useful in treating cancers.
