ADAMS JULIAN,FOLEY MICHAEL A,JANARDANAN NAIR SOMARAJAN NAIR,NEVALAINEN MARTA,PORTER JAMES R,TREMBLAY MARTIN,CASTRO ALFREDO C
申请号：
IN744/KOLNP/2007
公开号：
IN262780B
申请日:
2007.02.28
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention discloses compositions and methods for modulating smoothened dependent pathway activation. The present invention also discloses analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
