Use of a smoothened inhibitor and a pi3 kinase inhibitor in the preparation of a combination medicament for the treatment of a hedgehog related cancer or tumor
The invention provides methods for modulating, e.g., antagonizing, the activity of the Hedgehog signaling pathway, and for treating Hedgehog related disorders such as cancers (e.g., medulloblastoma). In particular, the invention provides methods for inhibiting aberrant growth states resulting from phenotypes such as Ptch loss-of function, Hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function by administering to a mammal combinations of Smoothened inhibitors (e.g., a compound of Formula I, Formula II, or Formula III, or any of the compounds listed herein or incorporated by reference) and Gli inhibitors, and/or Phosphatidylinositol 3-kinase (PI3K) inhibitors.
