Adams, Julian,Porter, James R,Castro, Alfredo C,Foley, Michael A,Nair, Somarajan Nair Janardanan,Nevalainen, Marta,Tremblay, Martin
申请号：
NO20071264
公开号：
NO341137B1
申请日:
2007.03.08
申请国别(地区):
NO
年份:
2017
代理人:
摘要：
The present invention provides a preparation method for analogs of cyclopamine of formula 1 that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
