Metalloenzyme inhibitor compounds

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专利权人:

Inc.;Viamet Pharmaceuticals (NC)

发明人:

HOEKSTRA, William,YATES, Christopher

申请号：

ES12858190

公开号：

ES2671387T3

申请日:

2012.12.10

申请国别(地区):

ES

年份:

2018

代理人:

摘要：

A compound of formula (I), in which: R1 is halogen； R2 is halogen； each R3 is independently cyano, haloalkyl, alkoxy, halogen, haloalkoxy, hydroxy, amino, -NR6R9, -SR10, -C (O) R10, optionally substituted haloalkyl, optionally substituted arylalkoxy, -C (O) NR6R7, -CH (OH ) - haloalkyl, optionally substituted alkyl, hydroxyalkyl, alkoxyalkyl, isocyano, cycloalkylaminocarbonyl, optionally substituted aryloxyalkyl, optionally substituted arylalkylthio, haloalkylthio, optionally substituted aralkylsulfonyl, optionally substituted arylalkylsulfinyl, optionally substituted heteroarylalkoxy, optionally substituted ariltioalquilfeniltioalquilo, or haloalkylcarbonyl； n is 0, 1, 2 or 3； R4 is phenyl optionally substituted with 0, 1, 2 or 3 independent R8； R5 is H, alkyl, phosphate, phosphite, alkoxyphosphate, or -C (O) alkyl optionally substituted with 1 or 2 amino； R6 is independently H or alkyl； R7 is independently H, optionally substituted alkyl or optionally substituted arylalkyl； each R8 is independently cyano, haloalkyl, alkoxy, halogen or haloalkoxy； each R9 is independently H, alkyl, -C (O) alkyl, -C (O) H, -C (O) haloalkyl, optionally substituted arylalkyl, or optionally substituted haloalkyl； each R10 is independently H, optionally substituted alkyl, optionally substituted aryl, optionally substituted heterocycloalkyl or optionally substituted arylalkyl； Ar2 is ** Formula ** R11 is optionally substituted phenyl, optionally substituted thienyl, pyrrolyl, furanyl, optionally substituted pyridyl, optionally substituted indolyl, optionally substituted benzofuranyl, or ** Formula ** R12 is R4, -C (O) R4, -C (O) R7, -SO2R4； MBG is tetrazolyl； in which "substituted" in all occurrences refers to alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aralkyl, heteroaralkyl, aryl, heteroaryl, halogen, haloalkyl, cyano, nitro, alkoxy, aryloxy, hydroxyl, hydroxylalkyl, oxo (is ie, carbonyl), carboxyl, formyl, alkylcarbonyl, alkylcarbonylalkyl, alkoxycarbonyl, alkylcarbonyloxy,

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