РОДРИГЕЗ САРМИЕНТО Роза Мария (CH),ВИХМАНН Юрген (DE)
申请号：
RU2013152142/04
公开号：
RU2013152142A
申请日:
2012.05.02
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. The compounds of formula (I) where n is 0, 1, 2, 3 or 4； Y is —C (O) - or —S (O) -； R is hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, adamantyl, heterocycloalkyl, aryl, aryl fused to heterocycloalkyl, heteroaryl, —NRR, hydroxy, alkoxy or haloalkoxy； where alkyl, alkenyl, alkynyl, haloalkyl, alkoxy and haloalkoxy are optionally substituted with one, two or three independent R； where cycloalkyl, adamantyl, heterocycloalkyl, aryl, aryl condensed with heterocycloalkyl, and heteroaryl are optionally substituted with one, two or three independent R； R, R are independently hydrogen, halogen, cyano, alkyl, haloalkyl, hydroxy, alkoxy or haloalkoxy； cyano, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, -C (O) NRR, -NRR, -NH (CO) -alkyl, hydroxy, alkoxy, haloalkoxy, oxo or -S (O) R； where cycloalkyl, heterocycloalkyl, aryl and heteroaryl are optionally substituted with one, two or three independent R； R is halogen, cyano, alkyl, haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, -C (O) NRR, -NRR, -NH (CO ) -alkyl, hydroxy, alkoxy, haloalkoxy, oxo or -S (O) R； where cycloalkyl, heterocycloalkyl, aryl and heteroaryl are optionally substituted with one, two or three substituents independently selected from halogen, cyano, alkyl, haloalkyl, hydroxy, alkoxy, haloalkoxy and oxo； R, R are independently hydrogen, alkyl, haloalkyl, cycloalkyl, cycloalkyl , heterocycloalkyl, heterocycloalkylalkyl, aryl or heteroaryl； and their pharmaceutically acceptable salts and esters. 2. The compounds of claim 1, wherein n is 0, 1, or 2.3. The compounds of claim 1, wherein Y is —C (O) -. 4. Compounds according to claim 1, where R�1. Соединения формулы (I)где n представляет собой 0, 1, 2, 3 или 4；Y представляет собой -С(О)- или -S(O)-；Rпредставляет собой водород, алкил, алкенил, алкинил, галоалкил, циклоалкил, адамантил, гетероциклоалкил, арил, арил, конденсированный с гетероциклоалкилом, гетероарил, -NRR, гидрокси, алкокси или галоалкокси； игде алкил, алкенил, алкинил, галоа
